Frequent Frameshift and Point Mutations in the SH Gene of Human Metapneumovirus Passaged In Vitro

During the preparation of recombinant derivatives of the CAN97-83 clinical isolate of human metapneumovirus (HMPV), consensus nucleotide sequencing of the recovered RNA genomes provided evidence of frequent sequence heterogeneity at a number of genome positions. This heterogeneity was suggestive of...

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Bibliographic Details
Main Authors: Biacchesi, Stéphane, Murphy, Brian R., Collins, Peter L., Buchholz, Ursula J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
Subjects:
Genetic Diversity and Evolution
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900297/
https://ncbi.nlm.nih.gov/pubmed/17376897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00128-07
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