Infection of Nonhuman Primates with Recombinant Human Metapneumovirus Lacking the SH, G, or M2-2 Protein Categorizes Each as a Nonessential Accessory Protein and Identifies Vaccine Candidates

Recombinant human metapneumovirus (HMPV) in which the SH, G, or M2 gene or open reading frame was deleted by reverse genetics was evaluated for replication and vaccine efficacy following topical administration to the respiratory tract of African green monkeys, a permissive primate host. Replication...

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Detalhes bibliográficos
Main Authors: Biacchesi, Stéphane, Pham, Quynh N., Skiadopoulos, Mario H., Murphy, Brian R., Collins, Peter L., Buchholz, Ursula J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1211552/
https://ncbi.nlm.nih.gov/pubmed/16160190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.19.12608-12613.2005
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