Chimeric Recombinant Human Metapneumoviruses with the Nucleoprotein or Phosphoprotein Open Reading Frame Replaced by That of Avian Metapneumovirus Exhibit Improved Growth In Vitro and Attenuation In Vivo

Chimeric versions of recombinant human metapneumovirus (HMPV) were generated by replacing the nucleoprotein (N) or phosphoprotein (P) open reading frame with its counterpart from the closely related avian metapneumovirus (AMPV) subgroup C. In Vero cells, AMPV replicated to an approximately 100-fold-...

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Detalhes bibliográficos
Main Authors: Pham, Quynh N., Biacchesi, Stéphane, Skiadopoulos, Mario H., Murphy, Brian R., Collins, Peter L., Buchholz, Ursula J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316028/
https://ncbi.nlm.nih.gov/pubmed/16306583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.24.15114-15122.2005
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