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Chimeric Recombinant Human Metapneumoviruses with the Nucleoprotein or Phosphoprotein Open Reading Frame Replaced by That of Avian Metapneumovirus Exhibit Improved Growth In Vitro and Attenuation In Vivo

Chimeric versions of recombinant human metapneumovirus (HMPV) were generated by replacing the nucleoprotein (N) or phosphoprotein (P) open reading frame with its counterpart from the closely related avian metapneumovirus (AMPV) subgroup C. In Vero cells, AMPV replicated to an approximately 100-fold-...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pham, Quynh N., Biacchesi, Stéphane, Skiadopoulos, Mario H., Murphy, Brian R., Collins, Peter L., Buchholz, Ursula J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Microbiology 2005
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC1316028/
https://ncbi.nlm.nih.gov/pubmed/16306583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.24.15114-15122.2005
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