Deletion of M2 Gene Open Reading Frames 1 and 2 of Human Metapneumovirus: Effects on RNA Synthesis, Attenuation, and Immunogenicity

The M2 gene of human metapneumovirus (HMPV) contains two overlapping open reading frames (ORFs), M2-1 and M2-2. The expression of separate M2-1 and M2-2 proteins from these ORFs was confirmed, and recombinant HMPVs were recovered in which expression of M2-1 and M2-2 was ablated individually or toget...

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Detalhes bibliográficos
Main Authors: Buchholz, Ursula J., Biacchesi, Stéphane, Pham, Quynh N., Tran, Kim C., Yang, Lijuan, Luongo, Cindy L., Skiadopoulos, Mario H., Murphy, Brian R., Collins, Peter L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1112115/
https://ncbi.nlm.nih.gov/pubmed/15890897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.11.6588-6597.2005
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