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Role of the Hydrophilic Channels of Simian Virus 40 T-Antigen Helicase in DNA Replication

The simian virus 40 (SV40) hexameric helicase consists of a central channel and six hydrophilic channels located between adjacent large tier domains within each hexamer. To study the function of the hydrophilic channels in SV40 DNA replication, a series of single-point substitutions were introduced...

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Main Authors: Wang, Weiping, Manna, David, Simmons, Daniel T.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2007
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900167/
https://ncbi.nlm.nih.gov/pubmed/17301125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00003-07
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