Ubiquitin-Independent Proteasomal Degradation of Fra-1 Is Antagonized by Erk1/2 Pathway-Mediated Phosphorylation of a Unique C-Terminal Destabilizer

Fra-1, a transcription factor that is phylogenetically and functionally related to the proto-oncoprotein c-Fos, controls many essential cell functions. It is expressed in many cell types, albeit with differing kinetics and abundances. In cells reentering the cell cycle, Fra-1 expression is transient...

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Bibliographic Details
Main Authors: Basbous, Jihane, Chalbos, Dany, Hipskind, Robert, Jariel-Encontre, Isabelle, Piechaczyk, Marc
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900028/
https://ncbi.nlm.nih.gov/pubmed/17371847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01776-06
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