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c-Fos Proto-Oncoprotein Is Degraded by the Proteasome Independently of Its Own Ubiquitinylation In Vivo

Prior ubiquitinylation of the unstable c-Fos proto-oncoprotein is thought to be required for recognition and degradation by the proteasome. Contradicting this view, we report that, although c-Fos can form conjugates with ubiquitin in vivo, nonubiquitinylatable c-Fos mutants show regulated degradatio...

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Udgivet i:Mol Cell Biol
Principais autores: Bossis, Guillaume, Ferrara, Patrizia, Acquaviva, Claire, Jariel-Encontre, Isabelle, Piechaczyk, Marc
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2003
Fag:
Gene Expression
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230311/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14517309/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.20.7425-7436.2003
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