c-Fos Proto-Oncoprotein Is Degraded by the Proteasome Independently of Its Own Ubiquitinylation In Vivo

Prior ubiquitinylation of the unstable c-Fos proto-oncoprotein is thought to be required for recognition and degradation by the proteasome. Contradicting this view, we report that, although c-Fos can form conjugates with ubiquitin in vivo, nonubiquitinylatable c-Fos mutants show regulated degradatio...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Bossis, Guillaume, Ferrara, Patrizia, Acquaviva, Claire, Jariel-Encontre, Isabelle, Piechaczyk, Marc
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2003
Soggetti:	Gene Expression
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC230311/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14517309/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/MCB.23.20.7425-7436.2003
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