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The Peptidyl Prolyl cis/trans Isomerase FKBP38 Determines Hypoxia-Inducible Transcription Factor Prolyl-4-Hydroxylase PHD2 Protein Stability
The heterodimeric hypoxia-inducible transcription factors (HIFs) are central regulators of the response to low oxygenation. HIF-α subunits are constitutively expressed but rapidly degraded under normoxic conditions. Oxygen-dependent hydroxylation of two conserved prolyl residues by prolyl-4-hydroxyl...
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Main Authors: | , , , , , , , , , |
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Format: | Artigo |
Sprog: | Inglês |
Udgivet: |
American Society for Microbiology
2007
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Fag: | |
Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1899990/ https://ncbi.nlm.nih.gov/pubmed/17353276 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01324-06 |
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