Hypoxia-inducible Factor Prolyl-4-hydroxylase PHD2 Protein Abundance Depends on Integral Membrane Anchoring of FKBP38

Prolyl-4-hydroxylase domain (PHD) proteins are 2-oxoglutarate and dioxygen-dependent enzymes that mediate the rapid destruction of hypoxia-inducible factor α subunits. Whereas PHD1 and PHD3 proteolysis has been shown to be regulated by Siah2 ubiquitin E3 ligase-mediated polyubiquitylation and protea...

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Detalhes bibliográficos
Main Authors: Barth, Sandra, Edlich, Frank, Berchner-Pfannschmidt, Utta, Gneuss, Silke, Jahreis, Günther, Hasgall, Philippe A., Fandrey, Joachim, Wenger, Roland H., Camenisch, Gieri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Protein Synthesis, Post-Translational Modification, and Degradation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2755711/
https://ncbi.nlm.nih.gov/pubmed/19546213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.032631
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