The Peptidyl Prolyl cis/trans Isomerase FKBP38 Determines Hypoxia-Inducible Transcription Factor Prolyl-4-Hydroxylase PHD2 Protein Stability

The heterodimeric hypoxia-inducible transcription factors (HIFs) are central regulators of the response to low oxygenation. HIF-α subunits are constitutively expressed but rapidly degraded under normoxic conditions. Oxygen-dependent hydroxylation of two conserved prolyl residues by prolyl-4-hydroxyl...

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Main Authors: Barth, Sandra, Nesper, Jutta, Hasgall, Philippe A., Wirthner, Renato, Nytko, Katarzyna J., Edlich, Frank, Katschinski, Dörthe M., Stiehl, Daniel P., Wenger, Roland H., Camenisch, Gieri
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2007
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1899990/
https://ncbi.nlm.nih.gov/pubmed/17353276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01324-06
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