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Sperm Abnormalities in Heterozygous Acid Sphingomyelinase Knockout Mice Reveal a Novel Approach for the Prevention of Genetic Diseases
Acid sphingomyelinase knockout mice are a model of the inherited human disorder types A and B Niemann-Pick disease. Herein, we show that heterozygous (ASMKO(+/−)) mice have two distinct sperm populations resembling those found in normal and mutant animals, respectively, and that these two population...
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| Autores principales: | , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Society for Investigative Pathology
2007
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1899442/ https://ncbi.nlm.nih.gov/pubmed/17525274 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2007.061002 |
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