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Emergence of virus escape mutants after immunization with epitope vaccine.

BALB/c and C57BL/6J mice were immunized with recombinant vaccines consisting of lymphocytic choriomeningitis virus CD8+ T-lymphocyte epitopes and a carrier protein. During challenge infection with WE strain lymphocytic choriomeningitis virus, mutants with alterations in distinct amino acid residues...

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Detalhes bibliográficos
Main Authors: Weidt, G, Deppert, W, Utermöhlen, O, Heukeshoven, J, Lehmann-Grube, F
Formato: Artigo
Idioma:Inglês
Publicado em: 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC189635/
https://ncbi.nlm.nih.gov/pubmed/7474135
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