Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas.

Evi-2, a common site of viral integration in BXH-2 myeloid lymphomas, is located within a large intron of the Nf1 tumor suppressor gene. Viral integration at Evi-2 appears to induce disease by disrupting normal Nf1 expression. During our attempts to characterize the nature of the proviruses located...

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Veröffentlicht in:	J Virol
Hauptverfasser:	Cho, B C, Shaughnessy, J D, Largaespada, D A, Bedigian, H G, Buchberg, A M, Jenkins, N A, Copeland, N G
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1995
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC189634/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7474134/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.69.11.7138-7146.1995
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