Frequent disruption of the Nf1 gene by a novel murine AIDS virus-related provirus in BXH-2 murine myeloid lymphomas.

Evi-2, a common site of viral integration in BXH-2 myeloid lymphomas, is located within a large intron of the Nf1 tumor suppressor gene. Viral integration at Evi-2 appears to induce disease by disrupting normal Nf1 expression. During our attempts to characterize the nature of the proviruses located...

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Hlavní autoři: Cho, B C, Shaughnessy, J D, Largaespada, D A, Bedigian, H G, Buchberg, A M, Jenkins, N A, Copeland, N G
Médium: Artigo
Jazyk:Inglês
Vydáno: 1995
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC189634/
https://ncbi.nlm.nih.gov/pubmed/7474134
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