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Crystal structure of the Sec4p·Sec2p complex in the nucleotide exchanging intermediate state

Vesicular transport during exocytosis is regulated by Rab GTPase (Sec4p in yeast), which is activated by a guanine nucleotide exchange factor (GEF) called Sec2p. Here, we report the crystal structure of the Sec2p GEF domain in a complex with the nucleotide-free Sec4p at 2.7 Å resolution. Upon comple...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
Main Authors: Sato, Yusuke, Fukai, Shuya, Ishitani, Ryuichiro, Nureki, Osamu
פורמט: Artigo
שפה:Inglês
יצא לאור: National Academy of Sciences 2007
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895945/
https://ncbi.nlm.nih.gov/pubmed/17488829
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701550104
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