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Crystal structure of the Sec4p·Sec2p complex in the nucleotide exchanging intermediate state
Vesicular transport during exocytosis is regulated by Rab GTPase (Sec4p in yeast), which is activated by a guanine nucleotide exchange factor (GEF) called Sec2p. Here, we report the crystal structure of the Sec2p GEF domain in a complex with the nucleotide-free Sec4p at 2.7 Å resolution. Upon comple...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2007
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895945/ https://ncbi.nlm.nih.gov/pubmed/17488829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0701550104 |
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