Antimyeloma activity of heat shock protein-90 inhibition

We show that multiple myeloma (MM), the second most commonly diagnosed hematologic malignancy, is responsive to hsp90 inhibitors in vitro and in a clinically relevant orthotopic in vivo model, even though this disease does not depend on HER2/neu, bcr/abl, androgen or estrogen receptors, or other hsp...

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Hauptverfasser: Mitsiades, Constantine S., Mitsiades, Nicholas S., McMullan, Ciaran J., Poulaki, Vassiliki, Kung, Andrew L., Davies, Faith E., Morgan, Gareth, Akiyama, Masaharu, Shringarpure, Reshma, Munshi, Nikhil C., Richardson, Paul G., Hideshima, Teru, Chauhan, Dharminder, Gu, Xuesong, Bailey, Charles, Joseph, Marie, Libermann, Towia A., Rosen, Neal S., Anderson, Kenneth C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: © 2006 by The American Society of Hematology 2006
Schlagworte:
Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895907/
https://ncbi.nlm.nih.gov/pubmed/16234364
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1158
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