Mdm2 inhibitor Nutlin-3a induces p53-mediated apoptosis by transcription-dependent and transcription-independent mechanisms and may overcome Atm-mediated resistance to fludarabine in chronic lymphocytic leukemia

Although TP53 mutations are rare in B-cell chronic lymphocytic leukemia (CLL), Mdm2 overexpression has been reported as an alternative cause of p53 dysfunction. We investigated the potential therapeutic use of nongenotoxic p53 activation by a small-molecule antagonist of Mdm2, Nutlin-3a, in CLL. Nut...

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Bibliografiska uppgifter
Huvudupphovsmän: Kojima, Kensuke, Konopleva, Marina, McQueen, Teresa, O'Brien, Susan, Plunkett, William, Andreeff, Michael
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society of Hematology 2006
Ämnen:
Neoplasia
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895860/
https://ncbi.nlm.nih.gov/pubmed/16543464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-12-5148
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