A MAPK/HNRPK pathway controls BCR/ABL oncogenic potential by regulating MYC mRNA translation

Altered mRNA translation is one of the effects exerted by the BCR/ABL oncoprotein in the blast crisis phase of chronic myelogenous leukemia (CML). Here, we report that in BCR/ABL(+) cell lines and in patient-derived CML blast crisis mononuclear and CD34(+) cells, p210(BCR/ABL) increases expression a...

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Autors principals: Notari, Mario, Neviani, Paolo, Santhanam, Ramasamy, Blaser, Bradley W., Chang, Ji-Suk, Galietta, Annamaria, Willis, Anne E., Roy, Denis C., Caligiuri, Michael A., Marcucci, Guido, Perrotti, Danilo
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2006
Matèries:
Neoplasia
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895740/
https://ncbi.nlm.nih.gov/pubmed/16293596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-09-3732
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