High levels of the BCR/ABL oncoprotein are required for the MAPK-hnRNP-E2–dependent suppression of C/EBPα-driven myeloid differentiation

The inability of myeloid chronic myelogenous leukemia blast crisis (CML-BC) progenitors to undergo neutrophil differentiation depends on suppression of C/EBPα expression through the translation inhibitory activity of the RNA-binding protein hnRNP-E2. Here we show that “oncogene dosage” is a determin...

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Bibliografiske detaljer
Main Authors: Chang, Ji Suk, Santhanam, Ramasamy, Trotta, Rossana, Neviani, Paolo, Eiring, Anna M., Briercheck, Edward, Ronchetti, Mattia, Roy, Denis C., Calabretta, Bruno, Caligiuri, Michael A., Perrotti, Danilo
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Hematology 2007
Fag:
Neoplasia
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1924762/
https://ncbi.nlm.nih.gov/pubmed/17475908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-03-078303
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