Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease

Pulmonary hypertension is prevalent in adult patients with sickle cell disease and is strongly associated with early mortality and markers of hemolysis, in particular, serum lactate dehydrogenase (LDH). Intravascular hemolysis leads to impaired bioavailability of nitric oxide (NO), mediated by NO sc...

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Detalhes bibliográficos
Main Authors: Kato, Gregory J., McGowan, Vicki, Machado, Roberto F., Little, Jane A., Taylor, James, Morris, Claudia R., Nichols, James S., Wang, Xunde, Poljakovic, Mirjana, Morris, Sidney M., Gladwin, Mark T.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Clinical Trials and Observations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895723/
https://ncbi.nlm.nih.gov/pubmed/16291595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2373
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