Dysregulated Arginine Metabolism, Hemolysis-Associated Pulmonary Hypertension and Mortality in Sickle Cell Disease

CONTEXT: Sickle cell disease is characterized by a state of nitric oxide (NO) resistance and limited bioavailability of L-arginine, the substrate for NO synthesis. We hypothesized that increased arginase activity and dysregulated arginine metabolism contribute to endothelial dysfunction, pulmonary h...

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Auteurs principaux: Morris, Claudia R., Kato, Gregory J., Poljakovic, Mirjana, Wang, Xunde, Blackwelder, William C., Sanchdev, Vandana, Hazen, Stanley L., Vichinsky, Elliott P., Morris, Sidney M., Gladwin, Mark T.
Format: Artigo
Langue:Inglês
Publié: 2005
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2065861/
https://ncbi.nlm.nih.gov/pubmed/15998894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.294.1.81
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