Sub-acute hemolysis in sickle cell mice causes priapism secondary to NO imbalance and PDE5 dysregulation

INTRODUCTION: Recent research suggests that priapism in Sickle Cell Disease (SCD) is due to dysregulation of penile erection homeostasis including alteration of nitric oxide synthase (NOS) and phosphodiesterase 5 (PDE5) activities by excessive levels of reactive oxygen species (ROS) released during...

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Detalhes bibliográficos
Publicado no:J Sex Med
Main Authors: Sopko, Nikolai A., Matsui, Hotaka, Hannan, Johanna L., Berkowitz, Dan, Champion, Hunter C., Hsu, Lewis L., Musicki, Biljana, Burnett, Arthur L., Bivalacqua, Trinity J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4600325/
https://ncbi.nlm.nih.gov/pubmed/26346631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jsm.12976
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