Beneficial Effect of the Nitric Oxide Donor Compound 3-(1,3-Dioxoisoindolin-2-yl)Benzyl Nitrate on Dysregulated Phosphodiesterase 5, NADPH Oxidase, and Nitrosative Stress in the Sickle Cell Mouse Penis: Implication for Priapism Treatment

Patients with sickle cell disease (SCD) display priapism, and dysregulated nitric oxide (NO) pathway may contribute to this condition. However, current therapies offered for the prevention of priapism in SCD are few. The 3-(1,3-dioxoisoindolin-2-yl)benzyl nitrate (compound 4C) was synthesized throug...

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Bibliografiska uppgifter
I publikationen:J Pharmacol Exp Ther
Huvudupphovsmän: Silva, Fábio H., Karakus, Serkan, Musicki, Biljana, Matsui, Hotaka, Bivalacqua, Trinity J., dos Santos, Jean L., Costa, Fernando F., Burnett, Arthur L.
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2016
Ämnen:
Drug Discovery and Translational Medicine
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074485/
https://ncbi.nlm.nih.gov/pubmed/27540002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.235473
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