Chargement en cours...

Beneficial Effect of the Nitric Oxide Donor Compound 3-(1,3-Dioxoisoindolin-2-yl)Benzyl Nitrate on Dysregulated Phosphodiesterase 5, NADPH Oxidase, and Nitrosative Stress in the Sickle Cell Mouse Penis: Implication for Priapism Treatment

Patients with sickle cell disease (SCD) display priapism, and dysregulated nitric oxide (NO) pathway may contribute to this condition. However, current therapies offered for the prevention of priapism in SCD are few. The 3-(1,3-dioxoisoindolin-2-yl)benzyl nitrate (compound 4C) was synthesized throug...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:J Pharmacol Exp Ther
Auteurs principaux: Silva, Fábio H., Karakus, Serkan, Musicki, Biljana, Matsui, Hotaka, Bivalacqua, Trinity J., dos Santos, Jean L., Costa, Fernando F., Burnett, Arthur L.
Format: Artigo
Langue:Inglês
Publié: The American Society for Pharmacology and Experimental Therapeutics 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074485/
https://ncbi.nlm.nih.gov/pubmed/27540002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.235473
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!