Beneficial Effect of the Nitric Oxide Donor Compound 3-(1,3-Dioxoisoindolin-2-yl)Benzyl Nitrate on Dysregulated Phosphodiesterase 5, NADPH Oxidase, and Nitrosative Stress in the Sickle Cell Mouse Penis: Implication for Priapism Treatment

Patients with sickle cell disease (SCD) display priapism, and dysregulated nitric oxide (NO) pathway may contribute to this condition. However, current therapies offered for the prevention of priapism in SCD are few. The 3-(1,3-dioxoisoindolin-2-yl)benzyl nitrate (compound 4C) was synthesized throug...

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Библиографические подробности
Опубликовано в: :J Pharmacol Exp Ther
Главные авторы: Silva, Fábio H., Karakus, Serkan, Musicki, Biljana, Matsui, Hotaka, Bivalacqua, Trinity J., dos Santos, Jean L., Costa, Fernando F., Burnett, Arthur L.
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2016
Предметы:
Drug Discovery and Translational Medicine
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074485/
https://ncbi.nlm.nih.gov/pubmed/27540002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.235473
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