Beneficial Effect of the Nitric Oxide Donor Compound 3-(1,3-Dioxoisoindolin-2-yl)Benzyl Nitrate on Dysregulated Phosphodiesterase 5, NADPH Oxidase, and Nitrosative Stress in the Sickle Cell Mouse Penis: Implication for Priapism Treatment

Patients with sickle cell disease (SCD) display priapism, and dysregulated nitric oxide (NO) pathway may contribute to this condition. However, current therapies offered for the prevention of priapism in SCD are few. The 3-(1,3-dioxoisoindolin-2-yl)benzyl nitrate (compound 4C) was synthesized throug...

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Udgivet i:J Pharmacol Exp Ther
Main Authors: Silva, Fábio H., Karakus, Serkan, Musicki, Biljana, Matsui, Hotaka, Bivalacqua, Trinity J., dos Santos, Jean L., Costa, Fernando F., Burnett, Arthur L.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society for Pharmacology and Experimental Therapeutics 2016
Fag:
Drug Discovery and Translational Medicine
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5074485/
https://ncbi.nlm.nih.gov/pubmed/27540002
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.116.235473
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