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Sildenafil Promotes eNOS Activation and Inhibits NADPH Oxidase in the Transgenic Sickle Cell Mouse Penis

INTRODUCTION: Sickle cell disease (SCD)-associated vasculopathy in the penis is characterized by aberrant nitric oxide and phosphodiesterase (PDE) 5 signaling, and by increased oxidative stress. Preliminary clinical trials show that continuous treatment with PDE5 inhibitor sildenafil unassociated wi...

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Bibliografiske detaljer
Main Authors: Musicki, Biljana, Bivalacqua, Trinity J., Champion, Hunter C., Burnett, Arthur L.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4011711/
https://ncbi.nlm.nih.gov/pubmed/24251665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jsm.12391
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