Lactate dehydrogenase as a biomarker of hemolysis-associated nitric oxide resistance, priapism, leg ulceration, pulmonary hypertension, and death in patients with sickle cell disease

Pulmonary hypertension is prevalent in adult patients with sickle cell disease and is strongly associated with early mortality and markers of hemolysis, in particular, serum lactate dehydrogenase (LDH). Intravascular hemolysis leads to impaired bioavailability of nitric oxide (NO), mediated by NO sc...

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Bibliografiske detaljer
Main Authors: Kato, Gregory J., McGowan, Vicki, Machado, Roberto F., Little, Jane A., Taylor, James, Morris, Claudia R., Nichols, James S., Wang, Xunde, Poljakovic, Mirjana, Morris, Sidney M., Gladwin, Mark T.
Format: Artigo
Sprog:Inglês
Udgivet: The American Society of Hematology 2006
Fag:
Clinical Trials and Observations
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895723/
https://ncbi.nlm.nih.gov/pubmed/16291595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2373
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