AKT induces erythroid-cell maturation of JAK2-deficient fetal liver progenitor cells and is required for Epo regulation of erythroid-cell differentiation

AKT serine threonine kinase of the protein kinase B (PKB) family plays essential roles in cell survival, growth, metabolism, and differentiation. In the erythroid system, AKT is known to be rapidly phosphorylated and activated in response to erythropoietin (Epo) engagement of Epo receptor (EpoR) and...

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Autores principales: Ghaffari, Saghi, Kitidis, Claire, Zhao, Wei, Marinkovic, Dragan, Fleming, Mark D., Luo, Biao, Marszalek, Joseph, Lodish, Harvey F.
Formato: Artigo
Lenguaje:Inglês
Publicado: © 2006 by The American Society of Hematology 2006
Materias:
Hematopoiesis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895702/
https://ncbi.nlm.nih.gov/pubmed/16254141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2304
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