Activating Notch1 mutations in mouse models of T-ALL

Recent studies have demonstrated that most patients with T-cell acute lymphocytic leukemia (T-ALL) have activating mutations in NOTCH1. We sought to determine whether these mutations are also acquired in mouse models of T-ALL. We sequenced the heterodimerization domain and the PEST domain of Notch1...

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Detalhes bibliográficos
Main Authors: O'Neil, Jennifer, Calvo, Jennifer, McKenna, Keith, Krishnamoorthy, Veena, Aster, Jon C., Bassing, Craig H., Alt, Frederick W., Kelliher, Michelle, Look, A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895623/
https://ncbi.nlm.nih.gov/pubmed/16166587
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-06-2553
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