Simultaneous activation of multiple signal transduction pathways confers poor prognosis in acute myelogenous leukemia

Deregulation of signal transduction pathways (STPs) may promote leukemogenesis by conferring cell proliferation and survival advantages in acute myelogenous leukemia (AML). Several agents targeting STPs are under development; however, redundancy and cross-talk between STPs could activate multiple do...

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Autores principales: Kornblau, Steven M., Womble, Matthew, Qiu, Yi Hua, Jackson, C. Ellen, Chen, Wenjing, Konopleva, Marina, Estey, Elihu H., Andreeff, Michael
Formato: Artigo
Lenguaje:Inglês
Publicado: The American Society of Hematology 2006
Materias:
Neoplasia
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895551/
https://ncbi.nlm.nih.gov/pubmed/16763210
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-02-003475
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