Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors

The cardiovascular safety of COX-2 selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) has recently been called into question. The factors that predispose to adverse events by NSAIDs are unknown. Because patients with arthritis have decreased nitric oxide (NO) bioavailability, t...

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Autori principali: Anning, Peter B., Coles, Barbara, Morton, Jonathan, Wang, Haibin, Uddin, Jashim, Morrow, Jason D., Dey, Sudhansu K., Marnett, Lawrence J., O'Donnell, Valerie B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society of Hematology 2006
Soggetti:
Hemostasis, Thrombosis, and Vascular Biology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895442/
https://ncbi.nlm.nih.gov/pubmed/16931629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-02-005330
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