Nitric oxide deficiency promotes vascular side effects of cyclooxygenase inhibitors

The cardiovascular safety of COX-2 selective and nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) has recently been called into question. The factors that predispose to adverse events by NSAIDs are unknown. Because patients with arthritis have decreased nitric oxide (NO) bioavailability, t...

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Detalhes bibliográficos
Main Authors: Anning, Peter B., Coles, Barbara, Morton, Jonathan, Wang, Haibin, Uddin, Jashim, Morrow, Jason D., Dey, Sudhansu K., Marnett, Lawrence J., O'Donnell, Valerie B.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society of Hematology 2006
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895442/
https://ncbi.nlm.nih.gov/pubmed/16931629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-02-005330
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