Mechanism for fetal hemoglobin induction by histone deacetylase inhibitors involves γ-globin activation by CREB1 and ATF-2

The histone deacetylase inhibitors (HDA-CIs) butyrate and trichostatin A activate γ-globin expression via a p38 mitogen-activating protein kinase (MAPK)-dependent mechanism. We hypothesized that down-stream effectors of p38 MAPK, namely activating transcription factor-2 (ATF-2) and cyclic AMP respon...

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Autori principali: Sangerman, Jose, Lee, Moo Seung, Yao, Xiao, Oteng, Eugene, Hsiao, Cheng-Hui, Li, Wei, Zein, Sima, Ofori-Acquah, Solomon F., Pace, Betty S.
Natura: Artigo
Lingua:Inglês
Pubblicazione: © 2006 by The American Society of Hematology 2006
Soggetti:
Red Cells
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895433/
https://ncbi.nlm.nih.gov/pubmed/16896160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2006-01-023713
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