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Polymerization of fibrin: specificity, strength, and stability of knob-hole interactions studied at the single-molecule level
Using laser tweezers, we measured for the first time the forces of individual knob-into-hole interactions underlying fibrin polymerization. Exposure of A-knobs in desA-fibrin or its fragment from the central part of the molecule (N-terminal disulphide knot, NDSK) resulted in strong interactions with...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society of Hematology
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895323/ https://ncbi.nlm.nih.gov/pubmed/15998829 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-2039 |
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