Molecular Mechanisms, Thermodynamics, and Dissociation Kinetics of Knob-Hole Interactions in Fibrin

Polymerization of fibrin, the primary structural protein of blood clots and thrombi, occurs through binding of knobs ‘A’ and ‘B’ in the central nodule of fibrin monomer to complementary holes ‘a’ and ‘b’ in the γ- and β-nodules, respectively, of another monomer. We characterized the A:a and B:b knob...

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Autori principali: Kononova, Olga, Litvinov, Rustem I., Zhmurov, Artem, Alekseenko, Andrey, Cheng, Chia Ho, Agarwal, Silvi, Marx, Kenneth A., Weisel, John W., Barsegov, Valeri
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2013
Soggetti:
Molecular Biophysics
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829353/
https://ncbi.nlm.nih.gov/pubmed/23720752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.472365
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