Molecular Mechanisms, Thermodynamics, and Dissociation Kinetics of Knob-Hole Interactions in Fibrin

Polymerization of fibrin, the primary structural protein of blood clots and thrombi, occurs through binding of knobs ‘A’ and ‘B’ in the central nodule of fibrin monomer to complementary holes ‘a’ and ‘b’ in the γ- and β-nodules, respectively, of another monomer. We characterized the A:a and B:b knob...

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Detalhes bibliográficos
Main Authors: Kononova, Olga, Litvinov, Rustem I., Zhmurov, Artem, Alekseenko, Andrey, Cheng, Chia Ho, Agarwal, Silvi, Marx, Kenneth A., Weisel, John W., Barsegov, Valeri
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829353/
https://ncbi.nlm.nih.gov/pubmed/23720752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.472365
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