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Mechanical Transition from α-Helical Coiled-Coils to β-Sheets in Fibrin(ogen)
We characterized the α-to-β transition in α-helical coiled-coil connectors of human fibrin(ogen) molecule using biomolecular simulations of their forced elongation, and theoretical modeling. The force (F) - extension (X) profiles show three distinct regimes: (1) the elastic regime, in which the coil...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3526676/ https://ncbi.nlm.nih.gov/pubmed/22953986 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja3076428 |
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