Molecular Mechanisms, Thermodynamics, and Dissociation Kinetics of Knob-Hole Interactions in Fibrin

Polymerization of fibrin, the primary structural protein of blood clots and thrombi, occurs through binding of knobs ‘A’ and ‘B’ in the central nodule of fibrin monomer to complementary holes ‘a’ and ‘b’ in the γ- and β-nodules, respectively, of another monomer. We characterized the A:a and B:b knob...

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Hauptverfasser: Kononova, Olga, Litvinov, Rustem I., Zhmurov, Artem, Alekseenko, Andrey, Cheng, Chia Ho, Agarwal, Silvi, Marx, Kenneth A., Weisel, John W., Barsegov, Valeri
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Molecular Biophysics
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829353/
https://ncbi.nlm.nih.gov/pubmed/23720752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.472365
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