Botrocetin/VWF-induced signaling through GPIb-IX-V produces TxA2 in an αIIbβ3- and aggregation-independent manner

Binding of von Willebrand factor (VWF) to the platelet membrane glycoprotein (GP) Ib-IX-V complex initiates a signaling cascade that causes αIIbβ3 activation and platelet aggregation. Previous work demonstrated that botrocetin (bt)/VWF–mediated agglutination activates αIIbβ3 and elicits adenosine tr...

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Hlavní autoři: Liu, Junling, Pestina, Tamara I., Berndt, Michael C., Jackson, Carl W., Gartner, T. Kent
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society of Hematology 2005
Témata:
Hemostasis, Thrombosis, and Vascular Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895306/
https://ncbi.nlm.nih.gov/pubmed/15985541
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1667
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