HTLV-1 Tax transgenic mice develop spontaneous osteolytic bone metastases prevented by osteoclast inhibition

One in 20 carriers of human T-cell leukemia virus type 1 (HTLV-1) will develop adult T-cell leukemia/lymphoma (ATL), a disease frequently associated with hypercalcemia, bone destruction, and a fatal course refractory to current therapies. Overexpression of the HTLV-1–encoded Tax oncoprotein under th...

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Detalhes bibliográficos
Main Authors: Gao, Ling, Deng, Hongju, Zhao, Haibo, Hirbe, Angela, Harding, John, Ratner, Lee, Weilbaecher, Katherine
Formato: Artigo
Idioma:Inglês
Publicado em: © 2005 by The American Society of Hematology 2005
Assuntos:
Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895233/
https://ncbi.nlm.nih.gov/pubmed/16118323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-04-1730
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