Recombinant CUB-1 domain polypeptide inhibits the cleavage of ULVWF strings by ADAMTS13 under flow conditions

The metalloprotease ADAMTS13 (a disintegrin and metalloprotease with thrombospondin motif) converts the hyperreactive unusually large (UL) forms of von Willebrand factor (VWF) that are newly released from endothelial cells into less active plasma forms by cleaving a peptide bond in the VWF A2 domain...

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Detalhes bibliográficos
Main Authors: Tao, Zhenyin, Peng, Yuandong, Nolasco, Leticia, Cal, Santiago, Lopez-Otin, Carlos, Li, Renhao, Moake, Joel L., López, José A., Dong, Jing-fei
Formato: Artigo
Idioma:Inglês
Publicado em: © 2005 by The American Society of Hematology 2005
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895231/
https://ncbi.nlm.nih.gov/pubmed/16141351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-05-2029
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