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Effects of Naturally Occurring Mutations in CUB-1 Domain on Synthesis, Stability, and Activity of ADAMTS-13
INTRODUCTION: Upon stimulation, endothelial cells release von Willebrand factor (VWF) in the unusually large (UL) and hyperactive forms that are rapidly cleaved by ADAMTS-13. Mutations in the ADAMTS13 gene result in ULVWF-mediated thrombosis found in patients with familial thrombotic thrombocytopeni...
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| Publicado no: | Thromb Res |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5649364/ https://ncbi.nlm.nih.gov/pubmed/19027144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.thromres.2008.09.007 |
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