Inhibitors of XIAP sensitize CD40-activated chronic lymphocytic leukemia cells to CD95-mediated apoptosis

Patients with chronic lymphocytic leukemia (CLL) treated with adenovirus CD154 (Ad-CD154, CD40 ligand [CD40L]) gene therapy experienced rapid reductions in leukemia cell counts and lymph node size associated with the induced expression of Fas (CD95). However, CLL cells initially resist CD95-mediated...

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Bibliografiska uppgifter
Huvudupphovsmän: Kater, Arnon P., Dicker, Frank, Mangiola, Massimo, Welsh, Kate, Houghten, Richard, Ostresh, John, Nefzi, Adel, Reed, John C., Pinilla, Clemencia, Kipps, Thomas J.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Hematology 2005
Ämnen:
Immunobiology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895220/
https://ncbi.nlm.nih.gov/pubmed/15914559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-02-0695
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