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Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development

GATA1 is mutated in patients with 2 different disorders. First, individuals with a GATA1 mutation that blocks the interaction between GATA-1 and its cofactor Friend of GATA-1 (FOG-1) suffer from dyserythropoietic anemia and thrombocytopenia. Second, children with Down syndrome who develop acute mega...

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Autors principals: Muntean, Andrew G., Crispino, John D.
Format: Artigo
Idioma:Inglês
Publicat: The American Society of Hematology 2005
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895209/
https://ncbi.nlm.nih.gov/pubmed/15860665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-02-0551
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