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Differential requirements for the activation domain and FOG-interaction surface of GATA-1 in megakaryocyte gene expression and development
GATA1 is mutated in patients with 2 different disorders. First, individuals with a GATA1 mutation that blocks the interaction between GATA-1 and its cofactor Friend of GATA-1 (FOG-1) suffer from dyserythropoietic anemia and thrombocytopenia. Second, children with Down syndrome who develop acute mega...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
The American Society of Hematology
2005
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895209/ https://ncbi.nlm.nih.gov/pubmed/15860665 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-02-0551 |
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