Potential approach to immunotherapy of chronic lymphocytic leukemia (CLL): enhanced immunogenicity of CLL cells via infection with vectors encoding for multiple costimulatory molecules

Chronic lymphocytic leukemia (CLL) is a disease of CD5(+) B lymphocytes (designated as CLL cells) that are inefficient antigen-presenting cells. Their poor ability to present antigens to the T cells, largely due to an inadequate costimulatory capacity, is manifested as a failure to stimulate prolife...

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Autors principals: Palena, Claudia, Foon, Kenneth A., Panicali, Dennis, Yafal, Alicia Gómez, Chinsangaram, Jarasvech, Hodge, James W., Schlom, Jeffrey, Tsang, Kwong Y.
Format: Artigo
Idioma:Inglês
Publicat: © 2005 by The American Society of Hematology 2005
Matèries:
Immunobiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895050/
https://ncbi.nlm.nih.gov/pubmed/16081691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2005-03-1214
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