An inducible caspase 9 safety switch for T-cell therapy

The efficacy of adoptive T-cell therapy as treatment for malignancies may be enhanced by genetic modification of infused cells. However, oncogenic events due to vector/transgene integration, and toxicities due to the infused cells themselves, have tempered enthusiasm. A safe and efficient means of r...

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Bibliographische Detailangaben
Hauptverfasser: Straathof, Karin C., Pulè, Martin A., Yotnda, Patricia, Dotti, Gianpietro, Vanin, Elio F., Brenner, Malcolm K., Heslop, Helen E., Spencer, David M., Rooney, Cliona M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: © 2005 by The American Society of Hematology 2005
Schlagworte:
Gene Therapy
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895037/
https://ncbi.nlm.nih.gov/pubmed/15728125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-11-4564
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