Endothelial apoptosis induced by inhibition of integrins αvβ3 and αvβ5 involves ceramide metabolic pathways

Matrix ligation of integrins αvβ3/αvβ5 is critical for endothelial survival and angiogenesis. We have previously shown that ceramide, a proapoptotic lipid second messenger, increases during endothelial anoikis (detachment-induced apoptosis). We now show that RGDfV, an integrin αvβ3/αvβ5 cyclic funct...

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Detalhes bibliográficos
Main Authors: Erdreich-Epstein, Anat, Tran, Linda B., Cox, Órla T., Huang, Elaine Y., Laug, Walter E., Shimada, Hiroyuki, Millard, Melissa
Formato: Artigo
Idioma:Inglês
Publicado em: © 2005 by The American Society of Hematology 2005
Assuntos:
Hemostasis, Thrombosis, and Vascular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1895032/
https://ncbi.nlm.nih.gov/pubmed/15705795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-08-3098
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