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Endothelial apoptosis induced by inhibition of integrins αvβ3 and αvβ5 involves ceramide metabolic pathways
Matrix ligation of integrins αvβ3/αvβ5 is critical for endothelial survival and angiogenesis. We have previously shown that ceramide, a proapoptotic lipid second messenger, increases during endothelial anoikis (detachment-induced apoptosis). We now show that RGDfV, an integrin αvβ3/αvβ5 cyclic funct...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
© 2005 by The American Society of Hematology
2005
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1895032/ https://ncbi.nlm.nih.gov/pubmed/15705795 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2004-08-3098 |
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