Proofreading and Secondary Structure Processing Determine the Orientation Dependence of CAG·CTG Trinucleotide Repeat Instability in Escherichia coli

Expanded CAG·CTG trinucleotide repeat tracts are associated with several human inherited diseases, including Huntington's disease, myotonic dystrophy, and spinocerebellar ataxias. Here we describe a new model system to investigate repeat instability in the Escherichia coli chromosome. Using thi...

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Hauptverfasser: Zahra, Rabaab, Blackwood, John K., Sales, Jill, Leach, David R. F.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Copyright © 2007 by the Genetics Society of America 2007
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Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1893049/
https://ncbi.nlm.nih.gov/pubmed/17339223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.069724
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