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Proofreading and Secondary Structure Processing Determine the Orientation Dependence of CAG·CTG Trinucleotide Repeat Instability in Escherichia coli
Expanded CAG·CTG trinucleotide repeat tracts are associated with several human inherited diseases, including Huntington's disease, myotonic dystrophy, and spinocerebellar ataxias. Here we describe a new model system to investigate repeat instability in the Escherichia coli chromosome. Using thi...
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| मुख्य लेखकों: | , , , |
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| स्वरूप: | Artigo |
| भाषा: | Inglês |
| प्रकाशित: |
Copyright © 2007 by the Genetics Society of America
2007
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| विषय: | |
| ऑनलाइन पहुंच: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1893049/ https://ncbi.nlm.nih.gov/pubmed/17339223 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.069724 |
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