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Proofreading and Secondary Structure Processing Determine the Orientation Dependence of CAG·CTG Trinucleotide Repeat Instability in Escherichia coli

Expanded CAG·CTG trinucleotide repeat tracts are associated with several human inherited diseases, including Huntington's disease, myotonic dystrophy, and spinocerebellar ataxias. Here we describe a new model system to investigate repeat instability in the Escherichia coli chromosome. Using thi...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Zahra, Rabaab, Blackwood, John K., Sales, Jill, Leach, David R. F.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Copyright © 2007 by the Genetics Society of America 2007
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC1893049/
https://ncbi.nlm.nih.gov/pubmed/17339223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.106.069724
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